Series of Screening Compounds with High Hit Rates for the Exploration of Multi-Target Activities and Assay Interference | Zendy

Dagmar Stumpfe | Zendy; Erik Gilberg | Zendy; Jürgen Bajorath | Zendy

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Series of Screening Compounds with High Hit Rates for the Exploration of Multi-Target Activities and Assay Interference

Author(s) -

Dagmar Stumpfe,

Erik Gilberg,

Jürgen Bajorath

Publication year - 2018

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2017-0137

Subject(s) - interference (communication) , computational biology , biology , pharmacology , medicine , computer science , telecommunications , channel (broadcasting)

Aim: Generation of a database of analog series (ASs) with high assay hit rates for the exploration of assay interference and multi-target activities of compounds. Methodology: ASs were computationally extracted from extensively tested screening compounds with high hit rates. Data: A total of 6941 ASs were assembled comprising 14,646 unique compounds that were tested in a total of 1241 different assays covering 426 specified targets. These ASs were organized and prioritized on the basis of different activity and assay frequency criteria. All ASs and associated information are made available in an open access deposition. Next steps: The large set of ASs will be further analyzed computationally and from a chemical perspective to identify assay interference compounds and candidates for exploring target promiscuity.

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