Functional Variants of TIM-3/HAVCR2 3′UTR in Lymphoblastoid Cell Lines | Zendy

Feifei Pu | Zendy; Fengxia Chen | Zendy; Z. Zhang | Zendy; Jing Feng | Zendy; Ping Xia | Zendy

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Functional Variants of TIM-3/HAVCR2 3′UTR in Lymphoblastoid Cell Lines

Author(s) -

Feifei Pu,

Fengxia Chen,

Z. Zhang,

Jing Feng,

Ping Xia

Publication year - 2018

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2017-0121

Subject(s) - single nucleotide polymorphism , international hapmap project , biology , minor allele frequency , genetics , microrna , three prime untranslated region , untranslated region , allele , genotype , computational biology , gene , messenger rna

Aim: Variants of TIM-3/HAVCR2 3′UTR miRNA binding sites are significantly associated with cancer; however, roles in post-transcriptional regulation have not been elucidated. Methods: The regulatory and coding region single nucleotide polymorphisms (SNPs) of TIM-3/HAVCR2 were identified using an online database. Single nucleotide polymorphism Function Prediction was used to predict potential functional relevance of miRNA binding sites. Results: The analysis indicated rs9313439, rs4704846, rs3087616 and rs1036199 affect possible miRNA binding sites in TIM-3/HAVCR2 3′UTR. We used additional data on genotypes and limited minor allele frequency >5% in the HapMap populations. Only rs3087616 and rs4704846 were significantly associated with TIM-3/HAVCR2 . Conclusion: Both rs3087616 and rs4704846 could be putative variants mediating post-transcriptional regulation of the TIM-3/HAVCR2 . Deeper understanding of how 3′UTR variants influence the activity by TIM-3/HAVCR2 for therapy against cancer.

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