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Aim:  Variants of  TIM-3/HAVCR2  3′UTR miRNA binding sites are significantly associated with cancer; however, roles in post-transcriptional regulation have not been elucidated.    Methods:  The regulatory and coding region single nucleotide polymorphisms (SNPs) of  TIM-3/HAVCR2  were identified using an online database. Single nucleotide polymorphism Function Prediction was used to predict potential functional relevance of miRNA binding sites.    Results:  The analysis indicated rs9313439, rs4704846, rs3087616 and rs1036199 affect possible miRNA binding sites in  TIM-3/HAVCR2  3′UTR. We used additional data on genotypes and limited minor allele frequency >5% in the HapMap populations. Only rs3087616 and rs4704846 were significantly associated with  TIM-3/HAVCR2 .    Conclusion:  Both rs3087616 and rs4704846 could be putative variants mediating post-transcriptional regulation of the  TIM-3/HAVCR2 . Deeper understanding of how 3′UTR variants influence the activity by  TIM-3/HAVCR2  for therapy against cancer.

Functional variants of TIM-3/HAVCR2 3′UTR in lymphoblastoid cell lines