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Aim:  Until now, identification of drug targets for treatment of patients with specific stages of colorectal cancer (CRC) has remained a challenging field of research. Herein, we aimed to identify the key genes and regulatory networks involved in each stage of CRC.    Results:  The results of gene expression profiles were integrated with protein–protein interaction networks, and topologically analyzed. The most important regulatory genes (e.g.,  CDK1 ,  UBC ,  ESR1  and  ATXN1 ) and signaling pathways (e.g., Wnt, MAPK and JAK-STAT) in CRC initiation, progression and metastasis were identified.  In vitro  analysis confirmed some  in silico  findings.    Conclusion:  Our study introduces functional hub genes, subnetworks, prioritizes signaling pathways and novel biomarkers in CRC that may guide further development of targeted therapy programs.

Key genes and regulatory networks involved in the initiation, progression and invasion of colorectal cancer