Key Genes and Regulatory Networks Involved in the Initiation, Progression and Invasion of Colorectal Cancer | Zendy

Matin Asghari | Zendy; Mohammad Foad Abazari | Zendy; Hanieh Bokharaei | Zendy; Maryam Nouri Aleagha | Zendy; Vahdat Poortahmasebi | Zendy; Hassan Askari | Zendy; Sepehr Torabinejad | Zendy; Abbas Ardalan | Zendy; Navid Negaresh | Zendy; Atousa Ataei | Zendy; Parisa Pazooki | Zendy; Mansour Poorebrahim | Zendy

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Key Genes and Regulatory Networks Involved in the Initiation, Progression and Invasion of Colorectal Cancer

Author(s) -

Matin Asghari,

Mohammad Foad Abazari,

Hanieh Bokharaei,

Maryam Nouri Aleagha,

Vahdat Poortahmasebi,

Hassan Askari,

Sepehr Torabinejad,

Abbas Ardalan,

Navid Negaresh,

Atousa Ataei,

Parisa Pazooki,

Mansour Poorebrahim

Publication year - 2018

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2017-0108

Subject(s) - colorectal cancer , biology , gene , key (lock) , cancer , cancer research , computational biology , medicine , bioinformatics , genetics , ecology

Aim: Until now, identification of drug targets for treatment of patients with specific stages of colorectal cancer (CRC) has remained a challenging field of research. Herein, we aimed to identify the key genes and regulatory networks involved in each stage of CRC. Results: The results of gene expression profiles were integrated with protein–protein interaction networks, and topologically analyzed. The most important regulatory genes (e.g., CDK1 , UBC , ESR1 and ATXN1 ) and signaling pathways (e.g., Wnt, MAPK and JAK-STAT) in CRC initiation, progression and metastasis were identified. In vitro analysis confirmed some in silico findings. Conclusion: Our study introduces functional hub genes, subnetworks, prioritizes signaling pathways and novel biomarkers in CRC that may guide further development of targeted therapy programs.

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