Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas? | Zendy

George Fotakopoulos | Zendy; Kostas N. Fountas | Zendy; Eleni Tsianaka | Zendy; Polikceni Kotlia | Zendy; Dimitrios Pachatouridis | Zendy; Thanos Paschalis | Zendy; Spyridon Voulgaris | Zendy

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Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas?

Author(s) -

George Fotakopoulos,

Kostas N. Fountas,

Eleni Tsianaka,

Polikceni Kotlia,

Dimitrios Pachatouridis,

Thanos Paschalis,

Spyridon Voulgaris

Publication year - 2017

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2017-0103

Subject(s) - neuroprotection , vestibular system , medicine , vestibular schwannomas , neuroscience , biology , audiology

Aim: To evaluate the possible superiority of outcome in patients with elevated IGF-I levels after vestibular schwannoma (VS) resection. Patients & methods: This retrospective study included 65 patients (34 male, 52.3%) with VS operated in between January 2009 and April 2014 (follow-up 3.2 ± 0.7 years). Preoperative or postoperative IGF-I levels were identified for each patient. Results: Patients were divided into two groups: Group A (small size tumor), 56 patients; and Group B (large size tumor), 9 cases. IGF-I levels in Group A (195.8 ± 32.9 ng/ml) were compared with those of Group B (242.2 ± 22.2 ng/ml) and were found to have statistically significant difference (p = 0.001). Conclusion: Increased IGF-I levels could hold a key role in nerve recovery in patients undergoing surgical resection of large VS.

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