A Prospective Clinical Study of the Implications of IL-8 in the Diagnosis, Aggressiveness and Prognosis of Prostate Cancer | Zendy

Thierry Roumeguère | Zendy; F. Legrand | Zendy; Elie Rassy | Zendy; Mehdi Idrissi Kaitouni | Zendy; Simone Albisinni | Zendy; Alexandre Fontaine Rousseau | Zendy; Michel Vanhaeverbeek | Zendy; Sandrine Rorive | Zendy; Christine Decaestecker | Zendy; Olivier Debeir | Zendy; Karim Zouaoui Boudjeltia | Zendy; Fouad Aoun | Zendy

Open Access

A Prospective Clinical Study of the Implications of IL-8 in the Diagnosis, Aggressiveness and Prognosis of Prostate Cancer

Author(s) -

Thierry Roumeguère,

F. Legrand,

Elie Rassy,

Mehdi Idrissi Kaitouni,

Simone Albisinni,

Alexandre Fontaine Rousseau,

Michel Vanhaeverbeek,

Sandrine Rorive,

Christine Decaestecker,

Olivier Debeir,

Karim Zouaoui Boudjeltia,

Fouad Aoun

Publication year - 2017

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2017-0084

Subject(s) - medicine , prostate cancer , perineural invasion , prostatectomy , prostate , prostate specific antigen , prospective cohort study , biopsy , prostate biopsy , immunohistochemistry , urology , cancer , oncology , gastroenterology , pathology

Aim: We evaluated the relationship between IL-8 and prostate cancer (PCa) with emphasis on diagnosis, aggressiveness and prognosis. Materials & methods: Prostate-specific antigen (PSA) and serum IL-8 were collected from patients undergoing prostate biopsy. IL-8 expression was evaluated on immunohistochemistry with IL-8 labeling index. Complete follow-up of this cohort was achieved over a period of up to 6 years with continuous follow-up of PSA levels. Results: Among 135 patients, serum IL-8 level did not correlate to the diagnosis or aggressiveness of PCa. In 52 radical prostatectomy specimens, a higher IL-8 labeling index was detected in the tumor areas (0.4 ± 0.2 vs 0.33 ± 0.2; p = 0,007) but did not correlate to any of the prognostic markers: D'Amico classification (p = 0.52), Gleason score (p = 0.45), perineural (p = 0.83) and capsular invasion (p = 0.75). No correlation was found to PSA biochemical-free failure. Conclusion: IL-8 serum level was not a significant predictor of diagnosis, aggressiveness or prognosis of PCa.

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