Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T 2 Contrast Agent for MRI and their Uptake in Liver | Zendy

Lamiaa M. A. Ali | Zendy; Pasquina Marzola | Zendy; Eleicolato | Zendy; Silvia Fiorini | Zendy; Marcelo de las Heras Guillamón | Zendy; Rafael Piñol | Zendy; Lierni Gabilondo | Zendy; Ángel Millán | Zendy; Fernando Palacio | Zendy

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Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as T ₂ Contrast Agent for MRI and their Uptake in Liver

Author(s) -

Lamiaa M. A. Ali,

Pasquina Marzola,

Eleicolato,

Silvia Fiorini,

Marcelo de las Heras Guillamón,

Rafael Piñol,

Lierni Gabilondo,

Ángel Millán,

Fernando Palacio

Publication year - 2017

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2017-0054

Subject(s) - superparamagnetism , mri contrast agent , nanoparticle , polymer , iron oxide , iron oxide nanoparticles , chemistry , magnetic nanoparticles , contrast (vision) , nanotechnology , materials science , nuclear chemistry , nuclear magnetic resonance , organic chemistry , magnetization , physics , quantum mechanics , artificial intelligence , magnetic field , computer science

Aim: To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T 2 magnetic resonance contrast agent and their uptake and toxicity in liver. Materials & methods: Mice were intravenously injected with bioferrofluids and Endorem ® . The magnetic resonance efficiency, uptake and in vivo toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques. Results: Bioferrofluids are a good T 2 contrast agent with a higher r 2 /r 1 ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection. Conclusion: Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection.

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