6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Attenuates Heptatocellular Carcinoma in Rats with NMR-Based Metabolic Perturbations | Zendy

Pranesh Kumar | Zendy; Ashok Kumar Singh | Zendy; Vinit Raj | Zendy; Amit Rai | Zendy; Siddhartha Maity | Zendy; Atul Rawat | Zendy; Umesh Kumar | Zendy; Dinesh Kumar | Zendy; Anand Prakash | Zendy; Anupam Guleria | Zendy; Sudipta Saha | Zendy

Open Access

6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid Attenuates Heptatocellular Carcinoma in Rats with NMR-Based Metabolic Perturbations

Author(s) -

Pranesh Kumar,

Ashok Kumar Singh,

Vinit Raj,

Amit Rai,

Siddhartha Maity,

Atul Rawat,

Umesh Kumar,

Dinesh Kumar,

Anand Prakash,

Anupam Guleria,

Sudipta Saha

Publication year - 2017

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2017-0008

Subject(s) - isoquinoline , carboxylic acid , chemistry , pharmacology , medicine , stereochemistry , biochemistry

Aim: 6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (M1) was synthesized and evaluated for in-vivo antiproliferative action in diethylnitrosamine-induced hepatocarcinogenic rats. Materials & methods: The antiproliferative effect of M1 was assessed by various biochemical parameters, histopathology of liver and HPLC analysis. Proton nuclear magnetic resonance-based serum metabolic study was implemented on rat sera to explore the effects of M1 on hepatocellular carcinoma-induced metabolic alterations. Results: M1 showed protective action on liver and restored the arrangement of liver tissues in normal proportion. HPLC analysis displayed a good plasma drug concentration after its oral administration. Score plots of partial least squares discriminate analysis models exhibited that M1 therapy ameliorated hepatocellular carcinoma-induced metabolic alterations which signified its antiproliferative potential. Conclusion: M1 manifested notable antiproliferative profile, and warrants further investigation for future anticancer therapy.

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