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Aim:  We evaluated the diagnostic value of blood thiamine metabolites for Alzheimer’s disease (AD) by using positron emission tomography with  11 C-Pittsburgh compound B ( 11 C-PiB PET) scanning.    Methods:  Thirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received  11 C-PiB PET scanning for the measurement of cerebral amyloid deposition.    Results:  Thiamine diphosphate (TDP) had 66.7% sensitivity and 80.0% specificity for AD diagnosis, while the γ-value representing the best combination of thiamine metabolites and age had 24.2% sensitivity and 100.0% specificity according to the cut-off value of our previous study.    Conclusion:  Blood TDP but not γ-value exhibited results significant for AD diagnosis.

Diagnostic value of blood thiamine metabolites in Alzheimer’s disease examined by 11C-PiB PET scanning

Diagnostic value of blood thiamine metabolites in Alzheimer’s disease examined by ¹¹C-PiB PET scanning