Diagnostic Value of Blood Thiamine Metabolites in Alzheimer’s Disease examined by 11 C-PiB PET Scanning | Zendy

Zhichun Chen | Zendy; Xiaoli Pan | Zendy; Guoqiang Fei | Zendy; Shumei Pan | Zendy; Weiqi Bao | Zendy; Shuhua Ren | Zendy; Yihui Guan | Zendy; Chunjiu Zhong | Zendy

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Diagnostic Value of Blood Thiamine Metabolites in Alzheimer’s Disease examined by ¹¹ C-PiB PET Scanning

Author(s) -

Zhichun Chen,

Xiaoli Pan,

Guoqiang Fei,

Shumei Pan,

Weiqi Bao,

Shuhua Ren,

Yihui Guan,

Chunjiu Zhong

Publication year - 2017

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2016-0087

Subject(s) - thiamine , positron emission tomography , pittsburgh compound b , medicine , nuclear medicine , alzheimer's disease , standardized uptake value , pathology , disease

Aim: We evaluated the diagnostic value of blood thiamine metabolites for Alzheimer’s disease (AD) by using positron emission tomography with 11 C-Pittsburgh compound B ( 11 C-PiB PET) scanning. Methods: Thirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received 11 C-PiB PET scanning for the measurement of cerebral amyloid deposition. Results: Thiamine diphosphate (TDP) had 66.7% sensitivity and 80.0% specificity for AD diagnosis, while the γ-value representing the best combination of thiamine metabolites and age had 24.2% sensitivity and 100.0% specificity according to the cut-off value of our previous study. Conclusion: Blood TDP but not γ-value exhibited results significant for AD diagnosis.

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