Identification of Filamin-A and -B As Potential Biomarkers for Prostate Cancer | Zendy

Niven R. Narain | Zendy; Anne R. Diers | Zendy; Arleide Lee | Zendy; Socheata Lao | Zendy; Joyce Chan | Zendy; Sally Schofield | Zendy; Joe Andreazi | Zendy; Rakibou Ouro-Djobo | Zendy; Joaquín J. Jiménez | Zendy; Tracey Friss | Zendy; Nikunj Tanna | Zendy; Aditee Dalvi | Zendy; Sihe Wang | Zendy; Dustin R. Bunch | Zendy; Yezhou Sun | Zendy; Wenfang Wu | Zendy; Khampaseuth Thapa | Zendy; Stéphane Gesta | Zendy; Leonardo O. Rodrigues | Zendy; Viatcheslav R. Akmaev | Zendy; Vivek K. Vishnudas | Zendy; Rangaprasad Sarangarajan | Zendy

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Identification of Filamin-A and -B As Potential Biomarkers for Prostate Cancer

Author(s) -

Niven R. Narain,

Anne R. Diers,

Arleide Lee,

Socheata Lao,

Joyce Chan,

Sally Schofield,

Joe Andreazi,

Rakibou Ouro-Djobo,

Joaquín J. Jiménez,

Tracey Friss,

Nikunj Tanna,

Aditee Dalvi,

Sihe Wang,

Dustin R. Bunch,

Yezhou Sun,

Wenfang Wu,

Khampaseuth Thapa,

Stéphane Gesta,

Leonardo O. Rodrigues,

Viatcheslav R. Akmaev,

Vivek K. Vishnudas,

Rangaprasad Sarangarajan

Publication year - 2016

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2016-0065

Subject(s) - flna , filamin , prostate cancer , biomarker discovery , biology , biomarker , proteomics , cancer research , cancer , pathology , computational biology , bioinformatics , medicine , genetics , gene , cytoskeleton , cell

Aim: A novel strategy for prostate cancer (PrCa) biomarker discovery is described. Materials & methods: In vitro perturbation biology, proteomics and Bayesian causal analysis identified biomarkers that were validated in in vitro models and clinical specimens. Results: Filamin-B (FLNB) and Keratin-19 were identified as biomarkers. Filamin-A (FLNA) was found to be causally linked to FLNB. Characterization of the biomarkers in a panel of cells revealed differential mRNA expression and regulation. Moreover, FLNA and FLNB were detected in the conditioned media of cells. Last, in patients without PrCa, FLNA and FLNB blood levels were positively correlated, while in patients with adenocarcinoma the relationship is dysregulated. Conclusion: These data support the strategy and the potential use of the biomarkers for PrCa.

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