Developmental Origin of Postnatal Cardiomyogenic Progenitor Cells | Zendy

YuanHung Liu | Zendy; LingPing Lai | Zendy; Shih-Yun Huang | Zendy; Yi-Shuan Lin | Zendy; ShinnChih Wu | Zendy; Chih-Jen Chou | Zendy; JiunnLee Lin | Zendy

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Developmental Origin of Postnatal Cardiomyogenic Progenitor Cells

Author(s) -

YuanHung Liu,

LingPing Lai,

Shih-Yun Huang,

Yi-Shuan Lin,

ShinnChih Wu,

Chih-Jen Chou,

JiunnLee Lin

Publication year - 2016

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2016-0006

Subject(s) - embryonic stem cell , enhancer , progenitor cell , microbiology and biotechnology , green fluorescent protein , stem cell , enhancer trap , biology , in vitro , gene expression , gene , genetics

Aim: To trace the cell origin of the cells involved in postnatal cardiomyogenesis. Materials & methods: Nkx2.5 enhancer-eGFP (Nkx2.5 enh-eGFP) mice were used to test the cardiomyogenic potential of Nkx2.5 enhancer-expressing cells. By analyzing Cre excision of activated Nkx2.5-eGFP+ cells from different lineage-Cre/Nkx2.5 enh-eGFP/ROSA26 reporter mice, we traced the developmental origin of Nkx2.5 enhancer-expressing cells. Results: Nkx2.5 enhancer-expressing cells could differentiate into striated cardiomyocytes both in vitro and in vivo . Nkx2.5-eGFP+ cells increased remarkably after experimental myocardial infarction (MI). The post-MI Nkx2.5-eGFP+ cells originated from the embryonic epicardial cells, not from the pre-existing cardiomyocytes, endothelial cells, cardiac neural crest cells or perinatal/postnatal epicardial cells. Conclusion: Postnatal Nkx2.5 enhancer-expressing cells are cardiomyogenic progenitor cells and originate from embryonic epicardium-derived cells.

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