Nitric oxide as a surgical adjuvant | Zendy

Aimee E. Krausz | Zendy; Adam Friedman | Zendy

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Nitric oxide as a surgical adjuvant

Author(s) -

Aimee E. Krausz,

Adam Friedman

Publication year - 2015

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fso.15.56

Subject(s) - medicine , nitric oxide , inflammation , perioperative , wound healing , ischemia , angiogenesis , adverse effect , adjuvant , bioinformatics , surgery , intensive care medicine , pharmacology , immunology , cancer research , biology

Advances in surgical technology have allowed for previously unconsidered therapeutic interventions. However, the complexity and invasiveness of surgical procedures are not without adverse consequences. Nitric oxide's fundamental role in a host of physiological processes, including angiogenesis, wound and bone healing, thromboresistance, smooth muscle relaxation and inflammation makes it a significant player in accelerating wound healing and mitigating the inflammation of ischemia reperfusion injury common to surgical procedures. In addition, the therapeutic properties of NO have been harnessed for the prophylactic treatment of implant infection and graft failure. In this article, we will discuss the mechanism by which NO mediates these processes, and its perioperative translational applications.

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