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Aim:  Food and medicinal applications of barberry date back to 2500 years ago. This study investigates  Berberis integerrima  impact on lymphocytic immune responses.    Materials & methods:  Balb/c splenocytes were treated by 0.001–1000 μg/ml of  B. integerrima aqueous and alcoholic extracts in presence of phytohemagglutinin and lipopolysaccharide mitogens. Cell proliferation was assayed and cytokines were measured using ELISA.    Results:  Both extracts suppressed proliferation of phytohemagglutinin stimulated splenocytes (as T cells), while alcoholic extract induced expansion of lipopolysaccharide activated cells (as B lymphocytes) and unstimulated cells (p < 0.05). Both barberry extracts suppressed IFN-γ production (p < 0.05) and enhanced IL-4, IL-10 and TGF-β release from splenocytes (p < 0.05).    Conclusion:  Both extracts could suppress T-cell and enhance B-cell proliferation and shift immune responses toward Th2.

Barberry's (Berberis integerrima) ingredients suppress T-cell response and shift immune responses toward Th2: an in vitro study