Brain Signaling Systems in the Type 2 Diabetes and Metabolic Syndrome: Promising Target to Treat and Prevent These Diseases | Zendy

А. О. Шпаков | Zendy; К. В. Деркач | Zendy; Lev M. Berstein | Zendy

Open Access

Brain Signaling Systems in the Type 2 Diabetes and Metabolic Syndrome: Promising Target to Treat and Prevent These Diseases

Author(s) -

А. О. Шпаков,

К. В. Деркач,

Lev M. Berstein

Publication year - 2015

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fso.15.23

Subject(s) - melanocortins , medicine , metabolic syndrome , type 2 diabetes mellitus , diabetes mellitus , bioinformatics , melanocortin , insulin , type 2 diabetes , leptin , lipid metabolism , neuroprotection , insulin resistance , endocrinology , hormone , biology , obesity

The changes in the brain signaling systems play an important role in etiology and pathogenesis of Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), being a possible cause of these diseases. Therefore, their restoration at the early stages of T2DM and MS can be regarded as a promising way to treat and prevent these diseases and their complications. The data on the functional state of the brain signaling systems regulated by insulin, IGF-1, leptin, dopamine, serotonin, melanocortins and glucagon-like peptide-1, in T2DM and MS, are analyzed. The pharmacological approaches to restoration of these systems and improvement of insulin sensitivity, energy expenditure, lipid metabolism, and to prevent diabetic complications are discussed.

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