Portable Nanoporous Electrical Biosensor for Ultrasensitive Detection of Troponin-T | Zendy

Nandhinee Radha Shanmugam | Zendy; Anjan Panneer Selvam | Zendy; Thomas Barrett | Zendy; Steven C. Kazmierczak | Zendy; Milin Nilesh Rana | Zendy; Shalini Prasad | Zendy

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Portable Nanoporous Electrical Biosensor for Ultrasensitive Detection of Troponin-T

Author(s) -

Nandhinee Radha Shanmugam,

Anjan Panneer Selvam,

Thomas Barrett,

Steven C. Kazmierczak,

Milin Nilesh Rana,

Shalini Prasad

Publication year - 2015

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fso.15.22

Subject(s) - troponin complex , detection limit , nanoporous , biosensor , dielectric spectroscopy , materials science , electrical impedance , troponin t , nanotechnology , biomedical engineering , troponin , analytical chemistry (journal) , medicine , chemistry , chromatography , electrode , electrochemistry , cardiology , engineering , myocardial infarction , electrical engineering

Aim: To demonstrate the design, fabrication and testing of a portable, label-free biosensor for ultrasensitive detection of the cardiac Troponin-T (cTnT) from patient blood. Materials & methods: The biosensor is comprised of a nanoporous membrane integrated on to a microelectrode sensor platform for nanoconfinement effects. Charge perturbations due to antigen binding are recorded as impedance changes using electrochemical impedance spectroscopy. Results: The measured impedance change is used to quantitatively determine the cTnT concentration from the tested sample. We were successful in detecting and quantifying cardiac Troponin-T from a 40-patient cohort. The limit of detection was 0.01 pg/ml. Conclusion: This novel technology has promising preliminary results for rapid and sensitive detection of cTnT.

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