Targeting the Bacterial SOS Response for New Antimicrobial Agents: Drug targets, Molecular Mechanisms and Inhibitors | Zendy

Thomas LanyonHogg | Zendy

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Targeting the Bacterial SOS Response for New Antimicrobial Agents: Drug targets, Molecular Mechanisms and Inhibitors

Author(s) -

Thomas LanyonHogg

Publication year - 2021

Publication title -

future medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.708

H-Index - 69

eISSN - 1756-8927

pISSN - 1756-8919

DOI - 10.4155/fmc-2020-0310

Subject(s) - sos response , recbcd , repressor lexa , biology , dna damage , antimicrobial , dna repair , drug resistance , antibiotic resistance , drug discovery , antimicrobial drug , drug , multiple drug resistance , computational biology , microbiology and biotechnology , dna , bacteria , genetics , bioinformatics , pharmacology , transcription factor , repressor , gene

Antimicrobial resistance is a pressing threat to global health, with multidrug-resistant pathogens becoming increasingly prevalent. The bacterial SOS pathway functions in response to DNA damage that occurs during infection, initiating several pro-survival and resistance mechanisms, such as DNA repair and hypermutation. This makes SOS pathway components potential targets that may combat drug-resistant pathogens and decrease resistance emergence. This review discusses the mechanism of the SOS pathway; the structure and function of potential targets AddAB, RecBCD, RecA and LexA; and efforts to develop selective small-molecule inhibitors of these proteins. These inhibitors may serve as valuable tools for target validation and provide the foundations for desperately needed novel antibacterial therapeutics.

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