Photoinactivation of ESKAPE Pathogens: Overview of Novel Therapeutic Strategy | Zendy

Joankonieczna | Zendy; Agata Woźniak | Zendy; Michał Pierański | Zendy; Aleksandra Rapacka-Zdończyk | Zendy; Patrycja Ogonowska | Zendy; Mariusz Grinholc | Zendy

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Photoinactivation of ESKAPE Pathogens: Overview of Novel Therapeutic Strategy

Author(s) -

Joankonieczna,

Agata Woźniak,

Michał Pierański,

Aleksandra Rapacka-Zdończyk,

Patrycja Ogonowska,

Mariusz Grinholc

Publication year - 2019

Publication title -

future medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.708

H-Index - 69

eISSN - 1756-8927

pISSN - 1756-8919

DOI - 10.4155/fmc-2018-0329

Subject(s) - antimicrobial , pseudomonas aeruginosa , microbiology and biotechnology , klebsiella pneumoniae , staphylococcus aureus , acinetobacter baumannii , acinetobacter , enterobacter , multiple drug resistance , enterococcus , antibiotic resistance , biology , drug resistance , antibiotics , bacteria , escherichia coli , biochemistry , genetics , gene

The emergence of antimicrobial drug resistance requires development of alternative therapeutic options. Multidrug-resistant strains of Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterobacter spp. are still the most commonly identified antimicrobial-resistant pathogens. These microorganisms are part of the so-called ‘ESKAPE’ pathogens to emphasize that they currently cause the majority of hospital acquired infections and effectively ‘escape’ the effects of antibacterial drugs. Thus, alternative, safer and more efficient antimicrobial strategies are urgently needed, especially against ‘ESKAPE’ superbugs. Antimicrobial photodynamic inactivation is a therapeutic option used in the treatment of infectious diseases. It is based on a combination of a photosensitizer, light and oxygen to remove highly metabolically active cells.

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