High Sensitivity Methods to Quantify Chloroquine and its Metabolite in Human Blood Samples Using LC–MS/MS | Zendy

Karnrawee Kaewkhao | Zendy; Kesinee Chotivanich | Zendy; Markus Winterberg | Zendy; Nicholas Day | Zendy; Joel Tärning | Zendy; Daniel Blessborn | Zendy

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High Sensitivity Methods to Quantify Chloroquine and its Metabolite in Human Blood Samples Using LC–MS/MS

Author(s) -

Karnrawee Kaewkhao,

Kesinee Chotivanich,

Markus Winterberg,

Nicholas Day,

Joel Tärning,

Daniel Blessborn

Publication year - 2019

Publication title -

bioanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.566

H-Index - 58

eISSN - 1757-6199

pISSN - 1757-6180

DOI - 10.4155/bio-2018-0202

Subject(s) - metabolite , chromatography , chemistry , liquid chromatography–mass spectrometry , mass spectrometry , biochemistry

Chloroquine is an antimalarial drug used in the treatment of Plasmodium vivax malaria. Three methods to quantify chloroquine and its metabolite in blood matrices were developed and validated. Methodology & results: Different high-throughput extraction techniques were used to recover the drugs from whole blood (50 μl), plasma (100 μl) and dried blood spots (15 μl as punched discs) followed by quantification with LC-MS/MS. The intra- and inter-batch precisions were below 15%, and thus meet regulatory acceptance criteria.

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