Open AccessDevelopment and Validation of LC–MS/MS with In-Source Collision-Induced Dissociation for The Quantification of Pegcantratinib in Human Skin Tumors
Author(s) -
Monique Zangarini,
Neil Rajan,
Marina Danilenko,
Philip Berry,
Silvio Traversa,
Gareth J. Veal
Publication year - 2017
Publication title -
bioanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.566
H-Index - 58
eISSN - 1757-6199
pISSN - 1757-6180
DOI - 10.4155/bio-2016-0199
Subject(s) - chemistry , chromatography , dissociation (chemistry) , detection limit , mass spectrometry
Pegcantratinib is a mini-PEGylated K252a derivative, under clinical evaluation as an anticancer agent acting through inhibition of the tropomyosin receptor kinase. A method for quantifying pegcantratinib in skin tumor biopsies of patients was required to determine tumor drug penetration.
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