LC–MS/MS-Based Quantification of Kynurenine Metabolites, Tryptophan, Monoamines and Neopterin in Plasma, Cerebrospinal Fluid and Brain | Zendy

René Fuertig | Zendy; Angelo Ceci | Zendy; Sandrine Camus | Zendy; Erwan Bézard | Zendy; Andreas H. Luippold | Zendy; Bastian Hengerer | Zendy

Open Access

LC–MS/MS-Based Quantification of Kynurenine Metabolites, Tryptophan, Monoamines and Neopterin in Plasma, Cerebrospinal Fluid and Brain

Author(s) -

René Fuertig,

Angelo Ceci,

Sandrine Camus,

Erwan Bézard,

Andreas H. Luippold,

Bastian Hengerer

Publication year - 2016

Publication title -

bioanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.566

H-Index - 58

eISSN - 1757-6199

pISSN - 1757-6180

DOI - 10.4155/bio-2016-0111

Subject(s) - neopterin , kynurenine , cerebrospinal fluid , monoamine neurotransmitter , tryptophan , chemistry , kynurenine pathway , chromatography , serotonin , pharmacology , medicine , biochemistry , receptor , amino acid

The kynurenine (KYN) pathway is implicated in diseases such as cancer, psychiatric, neurodegenerative and autoimmune disorders. Measurement of KYN metabolite levels will help elucidating the involvement of the KYN pathway in the disease pathology and inform drug development.

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