Quantitative Analysis of Methyl and Propyl Parabens in Neonatal DBS Using LC–MS/MS | Zendy

Shirish Yakkundi | Zendy; Hussain Mulla | Zendy; Hitesh Pandya | Zendy; M. Turner | Zendy; James C. McElnay | Zendy

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Quantitative Analysis of Methyl and Propyl Parabens in Neonatal DBS Using LC–MS/MS

Author(s) -

Shirish Yakkundi,

Hussain Mulla,

Hitesh Pandya,

M. Turner,

James C. McElnay

Publication year - 2016

Publication title -

bioanalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.566

H-Index - 58

eISSN - 1757-6199

pISSN - 1757-6180

DOI - 10.4155/bio-2016-0029

Subject(s) - paraben , chromatography , medicine , pharmacology , blood sampling , chemistry , preservative , food science

Excipients are used to overcome the chemical, physical and microbiological challenges posed by developing formulated medicines. Both methyl and propyl paraben are commonly used in pediatric liquid formulations. There is no data on systemic exposure to parabens in neonates. The European Study of Neonatal Exposure to Excipients project has investigated this. Results & methodology: DBS sampling was used to collect opportunistic blood samples. Parabens were extracted from the DBS and analyzed using a validated LC-MS/MS assay.

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