Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex | Zendy

Brijesh Singh | Zendy; Jitendra K. Mishra | Zendy; Akshyaya Pradhan | Zendy

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Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex

Author(s) -

Brijesh Singh,

Jitendra K. Mishra,

Akshyaya Pradhan

Publication year - 2015

Publication title -

portugaliae electrochimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.252

H-Index - 27

eISSN - 1647-1571

pISSN - 0872-1904

DOI - 10.4152/pea.201506323

Subject(s) - flutamide , characterization (materials science) , chemistry , medicine , materials science , nanotechnology , cancer , prostate cancer , androgen receptor

Cobalt complex with flutamide was synthesized and physico - chemically characterized by amperometr y , polarography, elemental analysis and IR spectrometry . After synthesiz ing the metal complex, it was evaluated for antibacterial and antifungal activities against various pathogenic microorganisms such as Streptococcus aureus, Prosteus mirabilis, Klebsiella pneumonia and Aspergillus niger, Nigrosporan sp Fung i . B16 - F10 melanoma cell and C - 57BL/6 mice have been used for anticancer screening of the metal complex for in vitro and in vivo study. The result of pharmacological studies with M: L revealed that the complex is more potent as compared to the pure drug as regards to its anticancer activity.

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