Free-radical degradation of high-molar-mass hyaluronan induced by ascorbate plus cupric ions: Testing of stobadine and its two derivatives in function as antioxidants | Zendy

Lubica Surovcikova-Machova | Zendy; Katarína Valachová | Zendy; Mária Baňasová | Zendy; Vladimír Šnirc | Zendy; Elena Priesolová | Zendy; Milan Nagy | Zendy; Ivo Juránek | Zendy; Ladislav Šoltés | Zendy

Open Access

Free-radical degradation of high-molar-mass hyaluronan induced by ascorbate plus cupric ions: Testing of stobadine and its two derivatives in function as antioxidants

Author(s) -

Lubica Surovcikova-Machova,

Katarína Valachová,

Mária Baňasová,

Vladimír Šnirc,

Elena Priesolová,

Milan Nagy,

Ivo Juránek,

Ladislav Šoltés

Publication year - 2012

Publication title -

general physiology and biophysics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.376

H-Index - 39

eISSN - 1338-4325

pISSN - 0231-5882

DOI - 10.4149/gpb_2012_006

Subject(s) - chemistry , scavenger , radical , degradation (telecommunications) , abts , nuclear chemistry , antioxidant , medicinal chemistry , organic chemistry , telecommunications , computer science , dpph

Stobadine·2HCl and its two hydrophilic derivatives SM1dM9dM10·2HCl and SME1i-ProC2·HCl were tested in the function of antioxidants on hyaluronan (HA) degradation induced by the Weissberger oxidative system [ascorbate plus Cu(II)]. As a primary method, rotational viscometry was applied, where the substance tested was added before or 1 h after the initiation of HA degradation. The most effective scavengers of •OH and peroxy-type radicals were recorded to be stobadine·2HCl and SME1i-ProC2·HCl, respectively. The most effective scavenger, determined by applying the ABTS assay, was stobadine·2HCl.

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