Association between interleukin 4 (IL-4) VNTR, gene polymorphism, and breast cancer susceptibility in Iranian population: experimental and web base analysis | Zendy

Mostafa Ibrahimi | Zendy; Behzad Jamalzei | Zendy; Marzie Akbari | Zendy; Reza Ibrahimi | Zendy; Mohammad Reza Alaei | Zendy; Maryam Moossavi | Zendy; Milad Khorasani | Zendy

Open Access

Association between interleukin 4 (IL-4) VNTR, gene polymorphism, and breast cancer susceptibility in Iranian population: experimental and web base analysis

Author(s) -

Mostafa Ibrahimi,

Behzad Jamalzei,

Marzie Akbari,

Reza Ibrahimi,

Mohammad Reza Alaei,

Maryam Moossavi,

Milad Khorasani

Publication year - 2018

Publication title -

bratislavské lekárske listy/bratislava medical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 32

eISSN - 1336-0345

pISSN - 0006-9248

DOI - 10.4149/bll_2018_116

Subject(s) - genotype , allele , breast cancer , genetics , biology , immunology , genetic predisposition , interleukin , population , gene , cytokine , cancer , medicine , environmental health

Breast cancer (BC) is one of the most common types of cancer and the second leading cause of cancer death among women. Epidemiological studies showed that BC is linked to genetic and environmental factors, and inheritance plays a key role in the pathobiology of this disease. Interleukin 4 (IL-4) is a key differentiation cytokine and is produced by Th2 and activates Th2 development. Hence the current study aimed to assess the possible association between interleukin 4 (IL-4) VNTR polymorphism, and BC susceptibility in a sample of Iranian population.

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