Open AccessElectroacupuncture ameliorates experimental colitis induced by acetic acid in rat
Author(s) -
Jeoung Woo Kang,
Tae Wan Kim,
JunHo La,
Tae Sik Sung,
Hyun Ju Kim,
Young Bae Kwon,
Jeum Yong Kim,
Il Suk Yang
Publication year - 2004
Publication title -
journal of veterinary science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 47
eISSN - 1976-555X
pISSN - 1229-845X
DOI - 10.4142/jvs.2004.5.3.189
Subject(s) - colitis , zusanli , electroacupuncture , acetic acid , antagonist , myeloperoxidase , motility , pharmacology , medicine , chemistry , endocrinology , receptor , inflammation , biochemistry , biology , pathology , acupuncture , alternative medicine , genetics
The effect of electroacupuncture (EA) on experimental colitis was investigated in Sprague-Dawley rats. Colitis was induced by intracolonic instillation of 4% acetic acid. EA (2 Hz, 0.05 ms, 2 V for 20 min) was applied to bilateral Hoku (LI-4) and Zusanli (ST-36) on 12 hrs and 36 hrs after induction of colitis. EA-treatment significantly reduced the macroscopic damage and the myeloperoxidase activity of colonic samples at 3 days post-induction of colitis. Colitic colon showed a decreased in vitro motility. However, colonic motility of EA-treated group was not significantly different from that of normal group. The anti-inflammatory effect of EA was not inhibited by a glucocorticoid receptor antagonist, RU-486, but suppressed by a beta-adrenoceptor antagonist, propranonol. These results suggest that EA-treatment has a beneficial effect on colitis, and its anti-inflammatory effect is mediated by beta-adrenoceptor activation but not by endogenous glucocorticoiddependent mechanism.
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