Glutamate and GABA concentrations in the cerebellum of novel ataxic mutant Pogo mice | Zendy

Ki Hyung Kim | Zendy; Jeoung Hee Ha | Zendy; SeungHyuk Chung | Zendy; Chul Tae Kim | Zendy; Sun Kyung Kim | Zendy; Byung Hwa Hyun | Zendy; Kazuhiko Sawada | Zendy; Yoshihiro Fukui | Zendy; Il Kwon Park | Zendy; Geun jwa Lee | Zendy; Bum Kyeong Kim | Zendy; NamSeob Lee | Zendy; YoungGil Jeong | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Glutamate and GABA concentrations in the cerebellum of novel ataxic mutant Pogo mice

Author(s) -

Ki Hyung Kim,

Jeoung Hee Ha,

SeungHyuk Chung,

Chul Tae Kim,

Sun Kyung Kim,

Byung Hwa Hyun,

Kazuhiko Sawada,

Yoshihiro Fukui,

Il Kwon Park,

Geun jwa Lee,

Bum Kyeong Kim,

NamSeob Lee,

YoungGil Jeong

Publication year - 2003

Publication title -

journal of veterinary science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 47

eISSN - 1976-555X

pISSN - 1229-845X

DOI - 10.4142/jvs.2003.4.3.209

Subject(s) - cerebellum , glutamate receptor , ataxia , mutant , chemistry , glutamic acid , neurotransmitter , cerebellar ataxia , excitatory postsynaptic potential , gamma aminobutyric acid , biochemistry , inhibitory postsynaptic potential , biology , neuroscience , pharmacology , amino acid , gene , receptor

The Pogo mouse is an autosomal recessive ataxic mutant that arose spontaneously in the inbred KJR/MsKist strain derived originally from Korean wild mice. The ataxic phenotype is characterized by difficulty in maintaining posture and side to side stability, faulty coordination between limbs and trunk, and the consequent inability to walk straight. In the present study, the cerebellar concentrations of glutamate and GABA were analyzed, since glutamate is a most prevalent excitatory neurotransmitter whereas gamma-aminobutyric acid (GABA) is one of the most abundant inhibitory neurotransmitters, which may be the main neurotransmitters related with the ataxia and epilepsy. The concentration of glutamate of cerebellum decreased significantly in ataxic mutant Pogo mouse compared to those of control mouse. However, GABA concentration was not decrease. These results suggested that the decrease in glutamate concentration may contribute to ataxia in mutant Pogo mouse.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research