Sequence analysis of canine LINE-1 elements and p53 gene in canine transmissible venereal tumor | Zendy

Young Ki Choi | Zendy; ChulJoong Kim | Zendy

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Sequence analysis of canine LINE-1 elements and p53 gene in canine transmissible venereal tumor

Author(s) -

Young Ki Choi,

ChulJoong Kim

Publication year - 2002

Publication title -

journal of veterinary science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 47

eISSN - 1976-555X

pISSN - 1229-845X

DOI - 10.4142/jvs.2002.3.4.285

Subject(s) - orfs , exon , biology , point mutation , gene , tumor suppressor gene , nucleic acid sequence , microbiology and biotechnology , mutation , mutant , open reading frame , sequence analysis , sequence (biology) , oncogene , transcription (linguistics) , suppressor , genetics , virology , peptide sequence , cell cycle , carcinogenesis , linguistics , philosophy

LINEs (long interspersed nuclear elements or long interspersed repeated DNA elements) contains two open reading frames (ORFs), ORF1 and ORF2. We analysed the ORF2 located in the 5' region to the first exon of oncogene c-myc in canine transmissible venereal tumor (TVT) cell. We also showed the transcription activation was induced by this TVT-LINE sequence using CAT assay. To identify the mutation of tumor suppressor gene, sequence analysis of p53 from TVT cell was performed. We identified the point mutation of 964 nucleotide (T-C) resulting in the change of amino acid (Phe-Ser) of p53 tumor suppressor protein.

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