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Relling, A. E., Loerch, S. C. and Reynolds, C. K. 2014. Intravenous glucagon like peptide-1 infusion does not affect dry matter intake or hypothalamic mRNA expression of neuropeptide Y, agouti related peptide and proopiomelanocortin in wethers. Can. J. Anim. Sci. 94: 357–362. The objectives of the present study were to determine the effects of jugular vein infusions of glucagon like peptide-1 (GLP-1) and dietary fat inclusion on dry matter intake, nutrient digestibility and hypothalamic mRNA concentration of neuropeptide Y, agouti related peptide, and proopiomelanocortin in growing sheep. Thirty-six wethers were used (40.7±3.3 kg BW). Treatments were a control diet (n=11), dietary addition (6% of dry matter) of Ca salts of palm oil fatty acids (n=12), or 6-d jugular vein infusions of 0.155 µg kg −1  body weight/day of GLP-1 (n=11). Hormone concentrations were measured in jugular vein plasma from samples taken on days 1, 4 and 6. On day 7, the wethers were slaughtered for hypothalamus collection to measure mRNA concentration. The dietary addition of 6% of Ca salts of palm oil increased plasma GLP-1 concentration (P 0.20), but increased neutral detergent fibre digestibility (P&lt;0.01). In conclusion, glucagon like peptide-1 infusion or feeding fat did not decrease dry matter intake or affect hypothalamic neuropeptide mRNA concentrations of sheep.

canadian journal of animal science

Intravenous glucagon like peptide-1 infusion does not affect dry matter intake or hypothalamic mRNA expression of neuropeptide Y, agouti related peptide and proopiomelatnocortin in wethers