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Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved inthe biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part ofthe 3?UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353CT polymorphism causing a prolineto leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in MurcianoGranadinagoats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. Thelack of significant associations suggests that the P118L substitution does not involve a functional change.Le facteur de transcription de´nomme´ Sterol regulatory element binding transcription factor 1 (SREBF1)re´gule l’expression des ge`nes implique´s dans la biosynthe`se des acides gras et du choleste´rol. Dans cette e´tude, nous avonsse´quence´ la quasi-totalite´ de la re´gion codante et une partie du la re´gion 3?UTR du ge`ne SREBF1 de la che`vre. Ce travail,nous a permis d’identifier un polymorphisme non-synonyme c.353CT causant la substitution d’une Proline en Leucine a`la position 118. L’e´tude d’association avec la composition du lait enregistre´e en che`vres Murciano-Granadina, a re´ve´le´seulement une tendance statistique reliant SREBF1 ge´notype et l’acide gras ome´ga-3 du lait. L’absence d’associationssignificatives sugge`re que la substitution P118L n’implique pas un changement fonctionnel

canadian journal of animal science

Short Communication: An association analysis between one missense polymorphism at the <i>SREBF1</i> gene and milk yield and composition traits in goats

Short Communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats