In Vivo Monitoring of Natural Killer Cell Trafficking during Tumor Immunotherapy | Zendy

Naomi S. Sta Maria | Zendy; Samuel Barnes | Zendy; Russell E. Jacobs | Zendy

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In Vivo Monitoring of Natural Killer Cell Trafficking during Tumor Immunotherapy

Author(s) -

Naomi S. Sta Maria,

Samuel Barnes,

Russell E. Jacobs

Publication year - 2014

Publication title -

magnetic resonance insights

Language(s) - English

Resource type - Journals

ISSN - 1178-623X

DOI - 10.4137/mri.s13145

Subject(s) - immunotherapy , natural killer cell , in vivo , cancer immunotherapy , immune system , innate immune system , adoptive cell transfer , biology , lymphokine activated killer cell , cell , immunology , cancer research , cytotoxicity , in vitro , t cell , interleukin 21 , biochemistry , genetics , microbiology and biotechnology

Natural killer (NK) cells are a crucial part of the innate immune system and play critical roles in host anti-viral, anti-microbial, and antitumor responses. The elucidation of NK cell biology and their therapeutic use are actively being pursued with 200 clinical trials currently underway. In this review, we outline the role of NK cells in cancer immunotherapies and summarize current noninvasive imaging technologies used to track NK cells in vivo to investigate mechanisms of action, develop new therapies, and evaluate efficacy of adoptive transfer.

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