Treatment of Myasthenia Gravis in Patients with Elderly Onset at Advanced Age | Zendy

Noriko Nishikawa | Zendy; Masahiro Nagai | Zendy; Tomoaki Tsujii | Zendy; Win Thiri Kyaw | Zendy; Nachi Tanabe | Zendy; Hirotaka Iwaki | Zendy; Hayato Yabe | Zendy; Rina Ando | Zendy; Masahiro Nomoto | Zendy

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Treatment of Myasthenia Gravis in Patients with Elderly Onset at Advanced Age

Author(s) -

Noriko Nishikawa,

Masahiro Nagai,

Tomoaki Tsujii,

Win Thiri Kyaw,

Nachi Tanabe,

Hirotaka Iwaki,

Hayato Yabe,

Rina Ando,

Masahiro Nomoto

Publication year - 2015

Publication title -

japanese clinical medicine

Language(s) - English

Resource type - Journals

ISSN - 1179-6707

DOI - 10.4137/jcm.s29601

Subject(s) - myasthenia gravis , medicine , tacrolimus , prednisolone , immunosuppression , age of onset , adverse effect , pediatrics , thymectomy , surgery , disease , transplantation

The number of patients with late-onset myasthenia gravis (MG) among patients ≥50 years has been increasing recently. We encountered three patients who developed elderly-onset MG at a particularly advanced age (≥80 years). All were female and positive for anti-acetylcholine receptor antibodies. About 4 years have passed since MG onset in all three patients and symptoms have been controlled without recurrence using a combination of oral low-dose prednisolone and tacrolimus. As many cases of elderly-onset MG do not require strong immunosuppression, we recommend minimum immunosuppressive treatment to avoid adverse events, particularly in patients at an advanced age of ≥80 years.

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