Mechanism of Hepatocyte Apoptosis | Zendy

Lei Cao | Zendy; Xi-Bing Quan | Zendy; Wenjiao Zeng | Zendy; Xiaoou Yang | Zendy; Ming-Jie Wang | Zendy

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Mechanism of Hepatocyte Apoptosis

Author(s) -

Lei Cao,

Xi-Bing Quan,

Wenjiao Zeng,

Xiaoou Yang,

Ming-Jie Wang

Publication year - 2016

Publication title -

journal of cell death

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.419

H-Index - 15

ISSN - 1179-0660

DOI - 10.4137/jcd.s39824

Subject(s) - apoptosis , hepatocyte , endoplasmic reticulum , mechanism (biology) , microbiology and biotechnology , oxidative stress , fatty liver , biology , immunology , cancer research , disease , medicine , pathology , biochemistry , in vitro , philosophy , epistemology

Hepatocyte apoptosis plays important roles in both the removal of external microorganisms and the occurrence and development of liver diseases. Different conditions, such as virus infection, fatty liver disease, hepatic ischemia reperfusion, and drug-induced liver injury, are accompanied by hepatocyte apoptosis. This review summarizes recent research on the mechanism of hepatocyte apoptosis involving the classical extrinsic and intrinsic apoptotic pathways, endoplasmic reticulum stress, and oxidative stress-induced apoptosis. We emphasized the major causes of apoptosis according to the characteristics of different liver diseases. Several concerns regarding future research and clinical application are also raised.

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