Inhibition of Apoptosis and Efficacy of Pan Caspase Inhibitor, Q-VD-OPh, in Models of Human Disease | Zendy

Chanel L.I. Keoni | Zendy; Thomas L. Brown | Zendy

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Inhibition of Apoptosis and Efficacy of Pan Caspase Inhibitor, Q-VD-OPh, in Models of Human Disease

Author(s) -

Chanel L.I. Keoni,

Thomas L. Brown

Publication year - 2015

Publication title -

journal of cell death

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.419

H-Index - 15

ISSN - 1179-0660

DOI - 10.4137/jcd.s23844

Subject(s) - apoptosis , caspase , programmed cell death , in vivo , disease , intrinsic apoptosis , homeostasis , microbiology and biotechnology , cell , pharmacology , inhibitor of apoptosis , biology , chemistry , cancer research , biochemistry , medicine , genetics

Apoptosis is physiological cell death required for the cellular maintenance of homeostasis, and caspases play a major role in the execution of this process. Numerous disorders occur when levels of apoptosis within an organism are excessive, and several studies have explored the possibility of using caspase inhibitors to prevent these disorders. Q-VD-OPh (quinolyl-valyl-O-methylaspartyl-[2,6-difluorophenoxy]-methyl ketone), a novel pan caspase inhibitor, has been used because of its efficacy to inhibit apoptosis at low concentrations, its ability to cross the blood-brain barrier, as well as being nontoxic in vivo. This review examines Q-VD-OPh's ability to inhibit apoptosis in several animal models of human disease.

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