Tryptophan Metabolism and Its Relationship with Depression and Cognitive Impairment among HIV-infected Individuals | Zendy

Michael R. Keegan | Zendy; Seetharamaiah Chittiprol | Zendy; Scott Letendre | Zendy; Alan Winston | Zendy; Dietmar Fuchs | Zendy; Adriano Boasso | Zendy; Jennifer E. Iudicello | Zendy; Ronald J. Ellis | Zendy

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Tryptophan Metabolism and Its Relationship with Depression and Cognitive Impairment among HIV-infected Individuals

Author(s) -

Michael R. Keegan,

Seetharamaiah Chittiprol,

Scott Letendre,

Alan Winston,

Dietmar Fuchs,

Adriano Boasso,

Jennifer E. Iudicello,

Ronald J. Ellis

Publication year - 2016

Publication title -

international journal of tryptophan research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.405

H-Index - 23

ISSN - 1178-6469

DOI - 10.4137/ijtr.s36464

Subject(s) - neopterin , kynurenine , medicine , major depressive disorder , depression (economics) , logistic regression , cd38 , kynurenine pathway , gastroenterology , endocrinology , psychiatry , biology , tryptophan , biochemistry , genetics , macroeconomics , stem cell , amino acid , amygdala , cd34 , economics

Cognitive impairment (CI) and major depressive disorder (MDD) remain prevalent in treated HIV-1 disease; however, the pathogenesis remains elusive. A possible contributing mechanism is immune-mediated degradation of tryptophan (TRP) via the kynurenine (KYN) pathway, resulting in decreased production of serotonin and accumulation of TRP degradation products. We explored the association of these biochemical pathways and their relationship with CI and MDD in HIV-positive (HIV+) individuals.

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