Open AccessMethod for Evaluation of the Requirements of B-group Vitamins Using Tryptophan Metabolites in Human Urine
Author(s) -
Katsumi Shibata,
Junko Hirose,
Tsutomu Fukuwatari
Publication year - 2015
Publication title -
international journal of tryptophan research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.405
H-Index - 23
ISSN - 1178-6469
DOI - 10.4137/ijtr.s24412
Subject(s) - pantothenic acid , xanthurenic acid , tryptophan , niacin , urine , quinolinic acid , anthranilic acid , b vitamins , vitamin , kynurenic acid , chemistry , pyridoxine , metabolism , riboflavin , biochemistry , endocrinology , biology , amino acid
Tryptophan metabolism is directly involved with B-group vitamins such as vitamin B2, niacin, and vitamin B6, and indirectly with vitamin B1 and pantothenic acid. We evaluated the validity of requirements of B-group vitamins set by the Dietary Reference Intakes for the Japanese (DRI-J). We investigated the fate of dietary tryptophan in 10 Japanese adult men who ate the same diet based on DRI-J during a 4-week study. Vitamin mixtures were administered based on the amounts in the basal diet during weeks 2, 3, and 4. Daily urine samples were collected eight times (days 1 and 5 in each week). Administration of vitamin mixtures had no effect on tryptophan metabolites such as anthranilic acid, kynurenic acid, xanthurenic acid, 3-hydroxyanthranilic acid, and quinolinic acid within individuals. Surplus administration of B-group vitamins against DRI-J requirements did not elicit beneficial effects on tryptophan metabolism. Our findings supported the requirements of B-group vitamins set by the DRI-J.
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