Immunohistochemical Studies of the Kynurenine Pathway in Morphea | Zendy

Rowland Noakes | Zendy; Nick Mellick | Zendy

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Immunohistochemical Studies of the Kynurenine Pathway in Morphea

Author(s) -

Rowland Noakes,

Nick Mellick

Publication year - 2013

Publication title -

international journal of tryptophan research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.405

H-Index - 23

ISSN - 1178-6469

DOI - 10.4137/ijtr.s13371

Subject(s) - eosinophilic fasciitis , morphea , immunohistochemistry , medicine , kynurenine pathway , indoleamine 2,3 dioxygenase , pathology , myalgia , dermatology , kynurenine , eosinophilia , immunology , biology , biopsy , tryptophan , biochemistry , amino acid

Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibility of activation of the kynurenine pathway in morphea, skin biopsies were taken from involved and non-involved sites in a series of three patients with morphea. Immunohistochemical stains for quinolinic acid and indoleamine 2,3-dioxygenase (IDO) were performed.

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