Transcriptomic Sequencing Reveals a Set of Unique Genes Activated by Butyrate-Induced Histone Modification | Zendy

Congjun Li | Zendy; Robert W. Li | Zendy; R.L. Baldwin | Zendy; Le Ann Blomberg | Zendy; Sitao Wu | Zendy; Weizhong Li | Zendy

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Transcriptomic Sequencing Reveals a Set of Unique Genes Activated by Butyrate-Induced Histone Modification

Author(s) -

Congjun Li,

Robert W. Li,

R.L. Baldwin,

Le Ann Blomberg,

Sitao Wu,

Weizhong Li

Publication year - 2016

Publication title -

gene regulation and systems biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.534

H-Index - 18

ISSN - 1177-6250

DOI - 10.4137/grsb.s35607

Subject(s) - epigenomics , transcriptome , butyrate , epigenetics , gene , biology , histone deacetylase , computational biology , histone , histone deacetylase inhibitor , rna seq , epigenome , gene expression , microbiology and biotechnology , genetics , bioinformatics , dna methylation , biochemistry , fermentation

Butyrate is a nutritional element with strong epigenetic regulatory activity as a histone deacetylase inhibitor. Based on the analysis of differentially expressed genes in the bovine epithelial cells using RNA sequencing technology, a set of unique genes that are activated only after butyrate treatment were revealed. A complementary bioinformatics analysis of the functional category, pathway, and integrated network, using Ingenuity Pathways Analysis, indicated that these genes activated by butyrate treatment are related to major cellular functions, including cell morphological changes, cell cycle arrest, and apoptosis. Our results offered insight into the butyrate-induced transcriptomic changes and will accelerate our discerning of the molecular fundamentals of epigenomic regulation.

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