Transcriptional Changes of Blood Eosinophils after Methacholine Inhalation Challenge in Asthmatics | Zendy

Scott J. Tebbutt | Zendy; JianQing He | Zendy; Amrit Singh | Zendy; Casey P. Shan | Zendy; Jian Ruan | Zendy; Chris Carlsten | Zendy

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Transcriptional Changes of Blood Eosinophils after Methacholine Inhalation Challenge in Asthmatics

Author(s) -

Scott J. Tebbutt,

JianQing He,

Amrit Singh,

Casey P. Shan,

Jian Ruan,

Chris Carlsten

Publication year - 2012

Publication title -

genomics insights

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.746

H-Index - 7

ISSN - 1178-6310

DOI - 10.4137/gei.s9125

Subject(s) - methacholine , transcriptome , eosinophil cationic protein , bronchoconstriction , asthma , eosinophil , medicine , immunology , ccr3 , eosinophil granule proteins , inhalation , gene chip analysis , microarray analysis techniques , microarray , inflammation , gene expression , biology , gene , lung , respiratory disease , chemokine , anesthesia , genetics , chemokine receptor

Methacholine challenge is commonly used within the asthma diagnostic algorithm. Methacholine challenge has recently been shown to induce airway remodelling in asthma via bronchoconstriction, without additional airway inflammation. We evaluated the effect of methacholine-induced bronchoconstriction on the peripheral whole-blood transcriptome.

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