MicroRNA (miRNA) Expression is Regulated by Butyrate-Induced Epigenetic Modulation of Gene Expression in Bovine Cells | Zendy

Congjun Li | Zendy; Robert W. Li | Zendy; Theodore H. Elsasser | Zendy

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MicroRNA (miRNA) Expression is Regulated by Butyrate-Induced Epigenetic Modulation of Gene Expression in Bovine Cells

Author(s) -

Congjun Li,

Robert W. Li,

Theodore H. Elsasser

Publication year - 2010

Publication title -

genetics and epigenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.38

H-Index - 10

ISSN - 1179-237X

DOI - 10.4137/geg.s6144

Subject(s) - microrna , epigenetics , gene expression , biology , histone , butyrate , regulation of gene expression , acetylation , gene expression profiling , gene , microarray analysis techniques , meg3 , microbiology and biotechnology , microarray , genetics , downregulation and upregulation , biochemistry , long non coding rna , fermentation

We present evidence that butyrate induced histone acetylation regulates miRNA expression. MicroRNA expression microarray profiling revealed that 35 miRNA transcripts are significantly ( P < 0.05) differentially expressed after cells were treated with 10 mM butyrate. Among them, 11 transcripts are differentially expressed very significantly ( P < 0.01). The functional and pathways analysis using MetaCore analytical suite shows differentially expressed miRNAs targeting some very important gene networks and differentially expressed miRNAs may interfere with butyrate induced modulation of gene expression and cellular functions. The data indicates the complicated interaction between miRNA and histone acetylation forms a highly integrated regulatory mechanism

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