Open AccessUHRF1 Links the Histone Code and DNA Methylation to Ensure Faithful Epigenetic Memory Inheritance
Author(s) -
Christian Bronner,
G. Fuhrmann,
Frédéric Chédin,
Marcella Macaluso,
Sirano DhePaga
Publication year - 2009
Publication title -
genetics and epigenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.38
H-Index - 10
ISSN - 1179-237X
DOI - 10.4137/geg.s3992
Subject(s) - histone methylation , histone code , epigenomics , biology , epigenetics , genetics , dna methylation , histone , cancer epigenetics , histone methyltransferase , computational biology , microbiology and biotechnology , dna , nucleosome , gene , gene expression
Epigenetics is the study of the transmission of cell memory through mitosis or meiosis that is not based on the DNA sequence. At the molecular level the epigenetic memory of a cell is embedded in DNA methylation, histone post-translational modifications, RNA interference and histone isoform variation. There is a tight link between histone post-translational modifications (the histone code) and DNA methylation, as modifications of histones contribute to the establishment of DNA methylation patterns and vice versa. Interestingly, proteins have recently been identified that can simultaneously read both methylated DNA and the histone code. UHRF1 fulfills these requirements by having unique structural domains that allow concurrent recognition of histone modifications and methylated DNA. Herein, we review our current knowledge of UHRF1 and discuss how this protein ensures the link between histone marks and DNA methylation. Understanding the molecular functions of this protein may reveal the physiological relevance of the linkage between these layers of epigenetic marks
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