Phylogenomic and Domain Analysis of Iterative Polyketide Synthases in Aspergillus Species | Zendy

Shu-Hsi Lin | Zendy; Miwa Yoshimoto | Zendy; PingChiang Lyu | Zendy; Chuan Yi Tang | Zendy; Masanori Arita | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Phylogenomic and Domain Analysis of Iterative Polyketide Synthases in Aspergillus Species

Author(s) -

Shu-Hsi Lin,

Miwa Yoshimoto,

PingChiang Lyu,

Chuan Yi Tang,

Masanori Arita

Publication year - 2012

Publication title -

evolutionary bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.502

H-Index - 32

ISSN - 1176-9343

DOI - 10.4137/ebo.s9796

Subject(s) - nonribosomal peptide , polyketide , polyketide synthase , biology , gene , computational biology , genetics , biosynthesis

Aspergillus species are industrially and agriculturally important as fermentors and as producers of various secondary metabolites. Among them, fungal polyketides such as lovastatin and melanin are considered a gold mine for bioactive compounds. We used a phylogenomic approach to investigate the distribution of iterative polyketide synthases (PKS) in eight sequenced Aspergilli and classified over 250 fungal genes. Their genealogy by the conserved ketosynthase (KS) domain revealed three large groups of nonreducing PKS, one group inside bacterial PKS, and more than 9 small groups of reducing PKS. Polyphyly of nonribosomal peptide synthase (NRPS)-PKS genes raised questions regarding the recruitment of the elegant conjugation machinery. High rates of gene duplication and divergence were frequent. All data are accessible through our web database at http://metabolomics.jp/wiki/Category:PK.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research