Molecular Phylogeny of Edge Hill Virus Supports its Position in the Yellow Fever Virus Group and Identifies a New Genetic Variant | Zendy

Joanne Macdonald | Zendy; Michael Poidinger | Zendy; J. S. Mackenzie | Zendy; Richard C. Russell | Zendy; Stephen L. Doggett | Zendy; A.K. Broom | Zendy; Debra A Phillips | Zendy; Joseph Potamski | Zendy; G. P. Gard | Zendy; Peter I Whelan | Zendy; Richard Weir | Zendy; Paul R. Young | Zendy; Debra J. Gendle | Zendy; Sheryl Maher | Zendy; Ross Barnard | Zendy; Roy A. Hall | Zendy

Open Access

Molecular Phylogeny of Edge Hill Virus Supports its Position in the Yellow Fever Virus Group and Identifies a New Genetic Variant

Author(s) -

Joanne Macdonald,

Michael Poidinger,

J. S. Mackenzie,

Richard C. Russell,

Stephen L. Doggett,

A.K. Broom,

Debra A Phillips,

Joseph Potamski,

G. P. Gard,

Peter I Whelan,

Richard Weir,

Paul R. Young,

Debra J. Gendle,

Sheryl Maher,

Ross Barnard,

Roy A. Hall

Publication year - 2010

Publication title -

evolutionary bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.502

H-Index - 32

ISSN - 1176-9343

DOI - 10.4137/ebo.s4966

Subject(s) - flavivirus , virus , virology , biology , zika virus , phylogenetics , yellow fever , population , genetic distance , genetic divergence , phylogenetic tree , flaviviridae , virus classification , evolutionary biology , genetics , genetic variation , genetic diversity , genome , viral disease , gene , medicine , environmental health

Edge Hill virus (EHV) is a mosquito-borne flavivirus isolated throughout Australia during mosquito surveillance programs. While not posing an immediate threat to the human population, EHV is a taxonomically interesting flavivirus since it remains the only member of the yellow fever virus (YFV) sub-group to be detected within Australia. Here we present both an antigenic and genetic investigation of collected isolates, and confirm taxonomic classification of the virus within the YFV-group. Isolates were not clustered based on geographical origin or time of isolation, suggesting that minimal genetic evolution of EHV has occurred over geographic distance or time within the EHV cluster. However, two isolates showed significant differences in antigenic reactivity patterns, and had a much larger divergence from the EHV prototype (19% nucleotide and 6% amino acid divergence), indicating a distinct subtype or variant within the EHV subgroup.

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