Apparent microRNA-Target-specific Histone Modification in Mammalian Spermatogenesis | Zendy

Yh. Taguchi | Zendy

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Apparent microRNA-Target-specific Histone Modification in Mammalian Spermatogenesis

Author(s) -

Yh. Taguchi

Publication year - 2015

Publication title -

evolutionary bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.502

H-Index - 32

ISSN - 1176-9343

DOI - 10.4137/ebo.s21832

Subject(s) - epigenetics , microrna , h3k4me3 , histone , biology , histone methylation , regulation of gene expression , epigenomics , genetics , histone methyltransferase , regulator , dna methylation , gene expression , computational biology , microbiology and biotechnology , gene , promoter

Epigenetics is an important mRNA expression regulator. However, how distinct epigenetic factors, such as microRNAs (miRNAs) and promoter methylation, cooperatively regulate mRNA expression is rarely discussed. Recently, apparent miRNA regulation of promoter methylation was identified by bioinformatic analysis; however, it has not yet been experimentally confirmed. If miRNA regulation of other epigenetic factors were identified, it would reveal another layer of epigenetic regulation. In this paper, histone modifications (H3K4me1, H3K4me3, H3K27me3, H3K27ac, H3K9ac, and H2AZ) during mammalian spermatogenesis were studied and the apparent miRNA-target-specific histone modification was investigated by bioinformatic analyses of publicly available datasets.

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