P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN) | Zendy

Ann E. Walts | Zendy; Juan Lechago | Zendy; Bing Hu | Zendy; MaryBeth Shwayder | Zendy; Lynn Sandweiss | Zendy; Shikha Bose | Zendy

Open Access

P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN)

Author(s) -

Ann E. Walts,

Juan Lechago,

Bing Hu,

MaryBeth Shwayder,

Lynn Sandweiss,

Shikha Bose

Publication year - 2008

Publication title -

clinical medicine pathology

Language(s) - English

Resource type - Journals

ISSN - 1178-1181

DOI - 10.4137/cpath.s501

Subject(s) - medicine , grading (engineering) , immunostaining , medical diagnosis , pathology , immunohistochemistry , civil engineering , engineering

Significant variation is reported in the diagnosis of HPV-associated AIN. We previously observed that band-like positivity for p16 in >90% of contiguous cells coupled with Ki67 positivity in >50% of lesional cells is strongly associated with high grade AIN. This study was undertaken to determine if addition of p16 and Ki67 immunostaining would reduce inter- and intraobserver variability in diagnosis and grading of AIN.

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