Ketoconazole Inhibits Ovulation as a Result of Arrest of Follicular Steroidogenesis in the Rat Ovary | Zendy

M. Ga�l | Zendy; Joseph Orly | Zendy

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Ketoconazole Inhibits Ovulation as a Result of Arrest of Follicular Steroidogenesis in the Rat Ovary

Author(s) -

M. Ga�l,

Joseph Orly

Publication year - 2014

Publication title -

clinical medicine insights reproductive health

Language(s) - English

Resource type - Journals

ISSN - 1179-5581

DOI - 10.4137/cmrh.s15887

Subject(s) - ovulation , follicular phase , medicine , endocrinology , ovary , human chorionic gonadotropin , ovulation induction , gonadotropin , induced ovulation , equine chorionic gonadotropin , ovarian follicle , biology , andrology , hormone

Ketoconazole (KCZ) is a known inhibitor of steroidogenic P450 enzymes in the adrenal cortex and the gonads. Previous studies examined the potential clinical use of KCZ for attenuation of ovarian response to gonadotropin treatments. This study aimed to use the superovuating rat model to explore the effect of KCZ on ovarian steroidogenesis, follicular function, and development toward ovulation.

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