Selective Inhibition of Steroidogenic Enzymes by Ketoconazole in Rat Ovary Cells | Zendy

M. Ga�l | Zendy; Joseph Orly | Zendy

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Selective Inhibition of Steroidogenic Enzymes by Ketoconazole in Rat Ovary Cells

Author(s) -

M. Ga�l,

Joseph Orly

Publication year - 2014

Publication title -

clinical medicine insights reproductive health

Language(s) - English

Resource type - Journals

ISSN - 1179-5581

DOI - 10.4137/cmrh.s14036

Subject(s) - cholesterol side chain cleavage enzyme , cyp17a1 , medicine , endocrinology , ketoconazole , ovary , aminoglutethimide , pregnenolone , testosterone (patch) , biology , chemistry , cytochrome p450 , enzyme , steroid , hormone , biochemistry , metabolism , aromatase , microbiology and biotechnology , antifungal , cancer , breast cancer

Ketoconazole (KCZ) is an anti-fungal agent extensively used for clinical applications related to its inhibitory effects on adrenal and testicular steroidogenesis. Much less information is available on the effects of KCZ on synthesis of steroid hormones in the ovary. The present study aimed to characterize the in situ effects of KCZ on steroidogenic enzymes in primary rat ovary cells.

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