Live Birth from Previously Vitrified Oocytes, after Trophectoderm Biopsy, Revitrification, and Transfer of a Euploid Blastocyst | Zendy

J. Grifo | Zendy; B. Hodes-Wertz | Zendy; Hsiao Ling Lee | Zendy; E. Ampeloquio | Zendy; Melicia Clarke-Williams | Zendy; Alexis Adler | Zendy; S. Munné | Zendy; Alan S. Berkeley | Zendy

Open Access

Live Birth from Previously Vitrified Oocytes, after Trophectoderm Biopsy, Revitrification, and Transfer of a Euploid Blastocyst

Author(s) -

J. Grifo,

B. Hodes-Wertz,

Hsiao Ling Lee,

E. Ampeloquio,

Melicia Clarke-Williams,

Alexis Adler,

S. Munné,

Alan S. Berkeley

Publication year - 2013

Publication title -

clinical medicine insights reproductive health

Language(s) - English

Resource type - Journals

ISSN - 1179-5581

DOI - 10.4137/cmrh.s11919

Subject(s) - blastocyst , vitrification , andrology , live birth , blastocyst transfer , embryo transfer , human fertilization , oocyte , gynecology , infertility , embryo , biology , biopsy , cryopreservation , medicine , embryogenesis , pregnancy , anatomy , pathology , genetics

Our objective is to describe a successful live birth from oocyte vitrification followed by thaw, fertilization, blastocyst culture, trophectoderm biopsy, vitrification, and subsequent thaw. Fifteen mature oocytes were frozen from a patient with uterine factor infertility. Thirteen oocytes survived the thaw, and five underwent trophectoderm biopsy and were refrozen. Three euploid embryos were obtained. A single euploid embryo was transferred in the second thaw cycle to a known recipient leading to the delivery of a normal male infant. This case report is proof of the concept that preimplantation screening and diagnosis is an option for fertility preservation patients.

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