Clinical Significance of Alk-1 Gene Abnormalities in Diffuse Large Cell Lymphoma
Author(s) -
Laila A. Korashy,
Heba M. ElZawahry,
Said Abdou,
D. Shahin,
Feryal Farouk Sherif,
Wael Farrag,
O. Abdel-Khalik,
Hoda Salem,
Amr El-Sebaaie
Publication year - 2012
Publication title -
clinical medicine insights oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 26
ISSN - 1179-5549
DOI - 10.4137/cmo.s9920
Subject(s) - chop , anaplastic lymphoma kinase , medicine , immunophenotyping , lymphoma , prednisone , vincristine , cyclophosphamide , fluorescence in situ hybridization , anaplastic large cell lymphoma , gastroenterology , pathology , large cell lymphoma , diffuse large b cell lymphoma , oncology , chemotherapy , immunology , biology , gene , chromosome , antigen , biochemistry , pleural effusion , malignant pleural effusion
To detect relative frequency of anaplastic lymphoma kinase (ALK-1) gene abnormality in diffuse large cell lymphoma (DLCL) using fluorescence in situ hybridization (FISH), and correlate its presence with clinicopathological features which may be useful for choice of therapy and predict survival in newly diagnosed cases.
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