Paroxysmal Nocturnal Hemoglobinuria Presenting with a Left Intraventricular Thrombus in a Patient with Prior Thymoma and Aplastic Anemia | Zendy

Yazan Migdady | Zendy; Adam J. Olszewski | Zendy

Open Access

Paroxysmal Nocturnal Hemoglobinuria Presenting with a Left Intraventricular Thrombus in a Patient with Prior Thymoma and Aplastic Anemia

Author(s) -

Yazan Migdady,

Adam J. Olszewski

Publication year - 2011

Publication title -

clinical medicine insights oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 26

ISSN - 1179-5549

DOI - 10.4137/cmo.s8442

Subject(s) - paroxysmal nocturnal hemoglobinuria , thymoma , medicine , aplastic anemia , immunosuppression , subclinical infection , thrombus , anemia , pediatrics , immunology , bone marrow

We report the case of a 37-year old man presenting with a left ventricular cardiac thrombus in the setting of subclinical paroxysmal nocturnal hemoglobinura (PNH) developing two years after immunosuppressive therapy for thymoma-associated aplastic anemia. The literature regarding the interplay between autoimmunity and immunosuppression, aplastic anemia, thymoma and the emergence of PNH is reviewed.

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