Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes | Zendy

Pankaj Taneja | Zendy; Sinan Zhu | Zendy; Dejan Maglic | Zendy; Eizabeth A. Fry | Zendy; Robert D. Kendig | Zendy; Kazushi Inoue | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Transgenic and Knockout Mice Models to Reveal the Functions of Tumor Suppressor Genes

Author(s) -

Pankaj Taneja,

Sinan Zhu,

Dejan Maglic,

Eizabeth A. Fry,

Robert D. Kendig,

Kazushi Inoue

Publication year - 2011

Publication title -

clinical medicine insights oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 26

ISSN - 1179-5549

DOI - 10.4137/cmo.s7516

Subject(s) - suppressor , biology , gene , knockout mouse , genetically modified mouse , tumor suppressor gene , transgene , cancer research , gene knockout , cell cycle , carcinogenesis , cell growth , conditional gene knockout , genetics , phenotype

Cancer is caused by multiple genetic alterations leading to uncontrolled cell proliferation through multiple pathways. Malignant cells arise from a variety of genetic factors, such as mutations in tumor suppressor genes (TSGs) that are involved in regulating the cell cycle, apoptosis, or cell differentiation, or maintenance of genomic integrity. Tumor suppressor mouse models are the most frequently used animal models in cancer research. The anti-tumorigenic functions of TSGs, and their role in development and differentiation, and inhibition of oncogenes are discussed. In this review, we summarize some of the important transgenic and knockout mouse models for TSGs, including Rb, p53, Ink4a/Arf, Brca1/2, and their related genes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research