The Presence of Precursors of Benign Pre-B Lymphoblasts (Hematogones) in the Bone Marrow of a Paediatric Patient with Cytomegalovirus Infection | Zendy

F Moreno-Madrid | Zendy; J Uberos | Zendy; Manuel Díaz-Molina | Zendy; Alejandro Ramirez-Arredondo | Zendy; P Jiménez-Gámiz | Zendy; Antonio MolinaCarballo | Zendy

Open Access

The Presence of Precursors of Benign Pre-B Lymphoblasts (Hematogones) in the Bone Marrow of a Paediatric Patient with Cytomegalovirus Infection

Author(s) -

F Moreno-Madrid,

J Uberos,

Manuel Díaz-Molina,

Alejandro Ramirez-Arredondo,

P Jiménez-Gámiz,

Antonio MolinaCarballo

Publication year - 2008

Publication title -

clinical medicine oncology

Language(s) - English

Resource type - Journals

ISSN - 1177-9314

DOI - 10.4137/cmo.s751

Subject(s) - medicine , pancytopenia , cytomegalovirus , bone marrow , lymphoblast , immunophenotyping , thrombocytopenic purpura , pathology , immunology , toxoplasmosis , bone marrow examination , herpesviridae , immune system , viral disease , antigen , human immunodeficiency virus (hiv) , biology , genetics , cell culture

Hematogones are normal B-lymphoid precursors that multiply in the bone marrow of small children and of adults with ferropenic anaemia, neuroblastoma or idiopathic thrombocytopenic purpura. They are not normally found in peripheral blood, and the immunophenotype is virtually indistinguishable from that of B lymphoblasts. We discuss the case of a 3-month infant with an active cytomegalovirus infection, with hepatitis and pancytopenia associated with 13% hematogones in the bone marrow.

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